ScienceAsia 50 (2024):ID 2024078 1-6 |doi:
10.2306/scienceasia1513-1874.2024.078
Role of Ca2+/cAMP signalling in cancer with concurrent hypertension
Zhenxing Hea,?, Junming Chenb,?, Qiang Wangc, Fenfen Zhangc, Jianshe Yanga,c,*
ABSTRACT: Cancer and hypertension have severely burdened the medical health system. Cumulative clinical findings
suggest an association between hypertension and cancer development, although the underlying mechanisms remain
unclear. Notably, a functional relationship between inflammation, hypertension, and cancer could explain the clinical
link between these diseases. Ca2+ homeostasis dysregulation seems to play a key role in these diseases. Ca2+
signalling
positively responds to inflammation. Furthermore, a core regulator of Ca2+ metabolism, cAMP, has been shown to
indirectly regulate pro- and anti-inflammatory responses. In this review, by introducing the innate biological nano
confinements and its potential function, we discussed the role of Ca2+
/cAMP signalling in inflammation, hypertension,
and cancer to understand the interaction between Ca2+
/cAMP signalling pathways and these diseases and finally
improve therapeutic strategies.
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| a |
Department of General Surgery, The Third People?s Hospital of Longgang District, Shenzhen & Shenzhen Clinical
Medical School, Guangdong Pharmaceutical University, Shenzhen 518115 China |
| b |
Minhang Hospital, Fudan University, Shanghai 201199 China |
| c |
Gansu Medical College, Pingliang 744000 China |
* Corresponding author, E-mail: 2305499@tongji.edu.cn
Received 27 Apr 2024, Accepted 8 Aug 2024
|
