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Research articles

ScienceAsia 44 (2018): 170-178 |doi: 10.2306/scienceasia1513-1874.2018.44.170

Phytochemicals, cytotoxicity, and genotoxicity of three Artocarpus species reveal arbutin in A. lacucha

Kowit Noikotra,b, Arunrat Chaveeracha,c,*, Runglawan Sudmoona,d, Tawatchai Taneea,e, Natcha Patarapadungkita,f

ABSTRACT:     Leaves of three Artocarpus species were hexane and ethanol extracted and chemically analysed. Cytotoxicity and genotoxicity tests were performed on peripheral blood mononuclear cells. The main phytochemical in the hexane extracts was (Z)-9-octadecenamide (oleamide). The ethanol extracts showed 21% 9,19-cyclolanost-24-en-3-ol in A. altilis, 19% n-hexadecanoic acid in A. heterophyllus, and 21% arbutin in A. lacucha. The hexane extract of A. altilis gave an IC50 of 0.00035 mg/ml but no IC50 values for A. heterophyllus and A. lacucha extracts. Ethanol extracts of A. altilis and A. lacucha had IC50 values of 0.868 and 0.218 mg/ml, respectively, but none for A. heterophyllus. All the hexane extracts showed non-significant DNA damage, while all the ethanol extracts significantly induced DNA damage (p<0.05). A. lacucha leaf is newly reported as an alternative source of arbutin.

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a Genetics and Environmental Toxicology Research Group, Khon Kaen University, Khon Kaen 40002 Thailand
b Department of Biology, Faculty of Science, Ramkhamhaeng University, Bangkok 10240 Thailand
c Department of Biology, Faculty of Science, Khon Kaen University, Khon Kaen 40002 Thailand
d Faculty of Law, Khon Kaen University, Khon Kaen 40002 Thailand
e Faculty of Environment and Resource Studies, Mahasarakham University, Maha Sarakham 44150 Thailand
f Department of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002 Thailand

* Corresponding author, E-mail: raccha@kku.ac.th

Received 22 Aug 2017, Accepted 7 Aug 2018