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Research articles

ScienceAsia 42(2016): 397-406 |doi: 10.2306/scienceasia1513-1874.2016.42.397

Charge-transfer interactions between nitrogen moieties as a basis for different drugs with a picric acid acceptor

Moamen S. Refata,b,*, Hosam A. Saada,c, Hala Eldarotid, Abdel Majid Adama, Mohamed A. Al-Omare, Ahmed M. Naglahe,f

ABSTRACT:     The present study investigated and compared the complexation properties of different nitrogen moieties as donors with picric acid as the acceptor. The moieties were triethylamine (TEA), hydrazine (Hyd), thiosemicarbazide (TSC), phenylhydrazine (Phy), and pyridine (Pyr). The composition and stoichiometry of the synthesized complexes were verified by spectrophotometric titration and elemental analysis. The formed complexes were characterized using IR, Raman, 1H NMR, and UV-Vis spectroscopy, and CHN elemental analysis. Thermogravimetric experiments were carried out to investigate the thermal properties of the complexes. The microstructure properties of these complexes were investigated using optical light microscope (OLM). The donation from the nitrogen moieties to the picric acid acceptor in decreasing order was found to be Hyd > TEA > TSC > Phy > Phr. Interestingly, the thermal degradation of the TSC complex led to sulphur atoms remaining as a final residual. The OLM micrograph patterns indicate the formation of high quality coloured crystals.

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a Department of Chemistry, Faculty of Science, Taif University, Al-Haweiah, P.O. Box 888, Zip Code 21974, Taif, Saudi Arabia
b Department of Chemistry, Faculty of Science, Port Said University, Port Said, Egypt
c Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt
d Department of Chemistry, Faculty of Education, Alzaeim Alazhari University, Khartoum, Sudan
e Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
f Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622-Dokki, Cairo, Egypt

* Corresponding author, E-mail: msrefat@yahoo.com

Received 27 May 2017, Accepted 0 0000