Research articles
ScienceAsia 52 (2026):ID 2026065 1-5 |doi:
10.2306/scienceasia1513-1874..065
I2CHCOCHI2/PPh3: A highly efficient reagent for iodination of alcohols
Korakot Saowalaka,?, Sorachat Tharamaka,?, Anchulee Pengsooka, Parinthorn Temyarasilpb,
Wanchai Pluempanupata,*
ABSTRACT: A new and versatile protocol for converting alcohols into alkyl iodides utilizing PPh3
/I2
CHCOCHI2
is
established. Under mild and neutral conditions, this reagent produced higher product yields when compared to
PPh3
/CI4
in the iodination of various alcohols. Competitive reactions with selected iodinating agents and CBr4
in 1H
NMR studies showed that the reactivity of I2
CHCOCHI2
was greater than general I2
/imidazole and N-iodosuccinimide
(NIS). Consequently, the PPh3
/I2
CHCOCHI2
condition provides one of the attractive alternatives for iodination.
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| a |
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Special Research Unit for Advanced
Magnetic Resonance, Faculty of Science, Kasetsart University, Bangkok 10900 Thailand |
| b |
Chemistry Program, Faculty of Science and Technology, Valaya Alongkorn Rajabhat University under the Royal
Patronage, Pathum Thani 13180 Thailand |
* Corresponding author, E-mail: fsciwcp@ku.ac.th
Received 24 Jul 2024, Accepted 0 0000
|
