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Research articles

ScienceAsia 35 (2009): 137-141 |doi: 10.2306/scienceasia1513-1874.2009.35.137

Anti HSV-1 activity of sulphoquinovosyl diacylglycerol isolated from Spirulina platensis

Nattayaporn Chirasuwan*, Ratana Chaiklahan, Prasat Kittakoop, Wanlop Chanasattru, Marasri Ruengjitchatchawalya, Morakot Tanticharoen, Boosya Bunnag

ABSTRACT:     Herpes simplex virus type 1 (HSV-1) causes a variety of infections in humans and can be found in many countries worldwide. Although the antiherpes drug, acyclovir, has been used very successfully, an acyclovir-resistant strain of HSV has recently been found in patients and drug toxicity has been reported with increasing use of it. As a potential alternative, it has been found that both a water soluble and a lipid extract of the microalga Spirulina platensis exhibit antiviral activity (HSV-1) in Vero cells. In this study, bioassay guided fractionation of a lipid extract from S. platensis led to the identification of sulphoquinovosyl diacylglycerol as the active antiviral agent. The chemical structure of this compound was confirmed by NMR and LC-mass spectroscopic analyses. Results from the study showed that the compound exhibited a remarkable activity against HSV-1 with an IC50 value of 6.8 µg/ml, which was comparable to that of acyclovir (1.5 µg/ml).

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Pilot Plant Development and Training Institute, King Mongkut's University of Technology Thonburi, 83 Moo 8, Thakham, Bangkhuntien, Bangkok 10150, Thailand

* Corresponding author, E-mail: nattayaporn@pdti.kmutt.ac.th

Received 24 Mar 2008, Accepted 30 Mar 2009