| Home  | About ScienceAsia  | Publication charge  | Advertise with us  | Subscription for printed version  | Contact us  
Editorial Board
Journal Policy
Instructions for Authors
Online submission
Author Login
Reviewer Login
Volume 48 Number 6
Volume 48 Number 5
Volume 48 Number 4
Volume 48 Number 3
Volume 48 Number 2
Volume 48S Number 1
Earlier issues
Volume 47 Number 5 Volume 47 Number 6 Volume 48 Number 1

previous article next article

Research articles

ScienceAsia 47 (2021): 682-689 |doi: 10.2306/scienceasia1513-1874.2021.089

Antioxidant, anti-inflammatory, and anti-Staphylococcal activities of Albizia lucidior (Steud.) I. C. Nielsen wood extracts

Pathompong Phuakleea,*, Bhanuz Dechayonta, Jitpisute Chunthorng-Orna, Onmanee Prajuabjindaa, Thana Juckmetab, Kitrawee Jiraratsatitc, Kanmanee Sukkasema, Khwanchanok Mokmuedd, Kitiya Yangthaworna

ABSTRACT:     Albizia lucidior (Steud.) I. C. Nielsen is a leguminous tropical hardwood tree that is of great interest as a herbal medicine. In this study, both ethanolic and aqueous extracts of A. lucidior wood were investigated. The phenolic and flavonoid contents of the extracts were measured, and the antioxidant and anti-inflammatory activities were evaluated by inhibition of tumor necrosis factor α and nitric oxide production. Cytotoxic activity against macrophages was determined by the MTT assay, and antimicrobial activities were tested against Staphylococcus aureus, methicillin resistant Staphylococcus aureus (MRSA), and Staphylococcus epidermidis, measuring the minimum inhibitory and bactericidal concentrations. The chemical composition of the extracts was analyzed by GC-MS. The aqueous extract had higher total phenolic content than the ethanolic extract. Both extracts had strong antioxidant activity in the DPPH assay, with respective IC50 values of 7.12 and 9.02 µg/ml. In the ABTS assay, the aqueous extract had a lower IC50 (9.50 µg/ml) than the ethanolic extract. The ethanolic extract significantly inhibited NO, but the aqueous extract showed no inhibitory activity. However, neither extract significantly inhibited TNF-α production. Significant antibacterial activity was found only in the ethanolic extract with an MIC and an MBC against S. aureus of 2.5 mg/ml and 5.0 mg/ml, respectively. From our knowledge, this is the first study of the antioxidant, anti-inflammatory, and anti-Staphylococcal activities of A. lucidior wood extracts. The significant anti-Staphylococcal activity should be further explored in preclinical studies.

Download PDF

139 Downloads 491 Views

a Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120 Thailand
b School of Medicine, Walailak University, Nakhon Si Thammarat 80160 Thailand
c Faculty of Public Health, Thammasat University, Pathum Thani 12120 Thailand
d Division of Applied Thai Traditional Medicine, Faculty of Public Health, Naresuan University, Phitsanulok 65000 Thailand

* Corresponding author, E-mail: thompong1986@gmail.com

Received 17 Feb 2021, Accepted 30 Jul 2021