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Volume 47 Number 5
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Volume 47S Number 1

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Research articles

ScienceAsia 47S (2021): 14-18 |doi: 10.2306/scienceasia1513-1874.2021.S002


Antioxidant and antimicrobial alkaloids isolated from twigs of Uvaria grandiflora Roxb.


Naowarat Kongkuma, Sariyarach Thanasansurapongb, Nakin Surapanichc, Wiyarat Kumutanatc, Chanchai Sukkumd, Chutima Kuhakarnb, Thaworn Jaipetchb, Vichai Reutrakulb, Sakchai Hongthongb,c,*

 
ABSTRACT:     Phytochemical investigation of the MeOH-EtOAc (1:1 v/v) soluble fraction partitioned from the MeOH extract of twigs of Uvaria grandiflora Roxb. led to the isolation of six known compounds including aristolactam AII (1), aristolactam BI (2), velutinam (3), griffithinam (4), isoursuline (5), and sinactine (6). Their structures were determined on the basis of spectroscopic analysis and comparison with the literature data. Described in this work is the first report of isoursuline (5), an azafluorene derivative, and sinactine (6), a tetrahydroepiberberine, being isolated from plants in the Uvaria genus. Antioxidant and antimicrobial activities of some isolated compounds were evaluated. Among screened compounds, velutinam (3) showed antioxidant activity in the DPPH radical scavenging assay.

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a Division of Chemistry, Faculty of Science and Technology, Surindra Rajabhat University, Surin 32000 Thailand
b Department of Chemistry and Center Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University, Bangkok 10400 Thailand
c Division of Chemistry, Faculty of Science and Technology, Rajabhat Rajanagarindra University, Chachoengsao 24000 Thailand
d Division of Occupational Health and Safety, Faculty of Science and Technology, Rajabhat Rajanagarindra University, Chachoengsao 24000 Thailand

* Corresponding author, E-mail: sakchai.hon@rru.ac.th

Received 11 Nov 2020, Accepted 19 Feb 2021