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Volume 46 Number 6

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Research articles

ScienceAsia 46 (2020): 671-678 |doi: 10.2306/scienceasia1513-1874.2020.095

Effects of oral administration of Garcinia dulcis flower extract on arterial blood pressure and renal excretory functions in rats

Nattaya Thongsepeea,b,*, Umarat Srisawata, Wilawan Mahabussarakamc, Sophapun Ekarattanawonga, Noppadon Suttirakd, Siriphun Hiranyachattadae

ABSTRACT:     Intravenous infusion of either camboginol or morelloflavone from Garcinia dulcis (GD) exerted diuretic, hypotensive, and vasorelaxant effects in either normotensive or hypertensive rats. This study aims to investigate the effects of GD flower extract on arterial blood pressure (ABP) and renal excretory functions. Male Wistar rats (8-weekold) were divided into 4 groups (group I?IV, n = 6 each) in both acute and sub-chronic protocols. The GD extract was orally administrated to group II?IV at the dose of 50, 100, or 200 mg/kg, respectively, while group I served as vehicle control. The oral administration was performed before the experiment in acute protocol and daily for 2 weeks in the sub-chronic protocol. The ABP and renal excretory functions were measured in the anesthetized rats. The levels of fasting blood glucose (FBG), plasma lipid profiles, and liver enzymes were evaluated in the sub-chronic experiment along with liver histology. The results showed that acute administration of GD extract significantly decreased ABP but increased renal blood flow, glomerular filtration rate, urine flow rate, osmolar clearance, and negative free water clearance when compared with the control. In the sub-chronic protocol, the GD extract significantly decreased ABP but did not alter the renal excretory functions. The plasma levels of FBG, lipid profiles, liver enzymes, and the histology of liver were not changed. It is concluded that acute oral administration of GD extract possessed hypotensive and diuretic effects whereas the sub-chronic treatment of GD showed hypotensive effect and no alterations in liver function, FBG, and plasma lipid profiles.

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a Department of Preclinical Science, Faculty of Medicine, Thammasat University, Pathum Thani 12120 Thailand
b Thammasat University Research Unit in Nutraceuticals and Food Safety, Faculty of Medicine, Thammasat University, Pathum Thani 12120 Thailand
c Division of Bioscience, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112 Thailand
d Laboratory Animal Center, Thammasat University, Pathum Thani 12120 Thailand
e School of Pharmacy, Walailak University, Nakhon Si Thammarat 80160 Thailand

* Corresponding author, E-mail: nattayat@tu.ac.th

Received 25 Mar 2020, Accepted 25 Oct 2020