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Volume 46 Number 6

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Research articles

ScienceAsia 46 (2020): 686-690 |doi: 10.2306/scienceasia1513-1874.2020.086


An effective invasive therapeutic approach of fluoro-substituted zinc phthalocyanine derivatives as potential photosensitizer for prostate carcinoma


Tamer E. Youssefa,b,*, Suhailah S. Al-Jameela, Wafa M. Al-Magribia

 
ABSTRACT:     Fluoro-substituted zinc(II)phthalocyanines (RS)4ZnPcs were prepared. All the structures of newly synthesized compounds was evaluated by IR and 1H NMR spectral analysis. They were tested against human adenocarcinoma prostate cancer cells. A type II membrane antigen highly expressed in prostate cancer, namely prostate-specific membrane antigen, has been an attractive target for imaging and therapy. To investigate the structureactivity relationships of (RS)4ZnPcs 4a?c in human adenocarcinoma prostate cancer cell model, 3 fluoro-substituted zinc(II)phthalocyanines with different terminal heteroaromatic rings have been designed and evaluated for their antiproliferative potency in vitro. The detailed LD50 values of the targeted compounds were reported. Our preliminary in vitro studies confirm that (RS)4ZnPcs 4a?c could act as an attractive photosensitizer for the early diagnosis of prostate cancer.

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a Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, Dammam 31441 Saudi Arabia.
b Basic and Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University, Dammam 31441 Saudi Arabia.

* Corresponding author, E-mail: temoustafa@iau.edu.sa

Received 14 Jan 2020, Accepted 30 Sep 2020