ScienceAsia 34 (2008): 043-047 |doi: 10.2306/scienceasia1513-1874.2008.34.043

Synthesis of Aliphatic Poly(ester-amide)s by Ring-Opening Polymerization of L-Lactide and Amino Acid Anhydrides

Cholticha Noomhorm^a* and Yutaka Tokiwa^b

 
ABSTRACT:     Poly(ester-amide)s were prepared by ring-opening copolymerization of L-lactide with glycine anhydride to form poly(lactide-co-glycine) and with alanine anhydride to form poly(lactide-co-alanine). At 195oC there were about 5.7 mol% inclusion of glycine using potassium tert-butoxide as catalyst in poly(lactide-co- glycine) and 5.0 mol% inclusion of alanine using tin(II) bis-2-ethylhexanoate as catalyst in poly(lactide-co- alanine). Enzymatic degradation studies showed that both copolymers could be degraded by proteinase K and glycine and alanine were included in their respective copolymers.

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a Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
b National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan. *

Corresponding author, E-mail: fscictn@ku.ac.th

Received 2 Mar 2007, Accepted 19 Sep 2007