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Research Articles

ScienceAsia 33 (2007): 057-060 |doi: 10.2306/scienceasia1513-1874.2007.33.057

Development of Oxytocin Nasal Gel using Natural Mucoadhesive Agent obtained from the Fruits of Dellinia indica. L.

Ketousetuo Kuotsu and Amal Kumar Bandyopadhyay*

ABSTRACT: A new nasal gel formulation has been developed using a natural mucoadhesive agent obtained from the fruit of Dellinia indica L. The mucoadhesive strength and viscosity of this natural mucoadhesive agent was found to be higher in comparison to the synthetic polymers, namely hydroxy propyl methyl cellulose (HPMC) and carbopol 934, which are conventionally used for a similar purpose. In vitro drug release characteristics using a Franz-diffusion cell and excised bovine nasal membrane was also found to be better in comparison to the above synthetic polymers. This patient friendly, needle free dosage form may replace the oxytocin injections in the future.

KEYWORDS: Oxytocin; dellinia indica L., mucoadhesive, nasal drug delivery, carbopol 934, hydroxypropyl methyl cellulose.

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Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700032, India.

* Corresponding author, E-mail: akbju@yahoo.com

Received 16 Dec 2005, Accepted 27 Jul 2006