ScienceAsia 32 (2006): 319-321 |doi: 10.2306/scienceasia1513-1874.2006.32.319

Sensitive Spectrophotometric determination of Metoclopramide Hydrochloride And Dapsone in Bulk Sample And Dosage Forms

Hosakere D. Revanasiddappa^* and Malligere A. Veena

 
ABSTRACT: A simple, sensitive and selective spectrophotometric method for the determination of metoclopramide hydrochloride (MCP) and dapsone (DAP) in both pure and dosage forms is described. The method is based on the diazo – coupling reaction of the studied drugs with a new coupling agent, imipramine hydrochloride, in an acid medium. The resulting violet – colored azo dyes exhibit maximum absorption at 570 nm for both MCP and DAP. All variables were studied in order to optimize the reaction conditions. The method is suitable for the determination of MCP and DAP in the presence of other ingredients that are usually present in dosage forms and the recoveries were obtained in the range of 99.5-100.5%. The results are reproducible with an accuracy of 1%, and the validity of the method was tested against reference method.

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Department of Chemistry, University of Mysore, Manasagangotri, Mysore – 570 006, India.

* Corresponding author, E-mail: hdrevanasiddappa@yahoo.com

Received 16 Feb 2005, Accepted 10 Feb 2006