ScienceAsia 28 (2002) : 087-092 |doi: 10.2306/scienceasia1513-1874.2002.28.087

Distribution of fibronectin, laminin, tenascin, chondroitin sulfate proteoglycan and HNK-1 epitope in the head region of homozygous rat small eye ( rSey) embryos

Suconta Chareonvit^*

ABSTRACT: Rat small eye (rSey) involves a mutation in Pax-6 gene. The midbrain crest cells of rSey homozygote fail to migrate normally towards the frontonasal region resulting in absence of eyes and nose. In the present study, comparison of the distribution patterns of fibronectin, laminin, tenascin, chondroitin sulfate proteoglycan and HNK-1 epitope in craniofacial region between that of rSey homozygous and the wild type embryos at the day 11 of gestation were investigated. The results showed alteration of distribution pattern of HNK-1 epitope at the mesenchyme adjacent to the frontonasal ectoderm where the Pax-6 gene was strongly expressed. However, the other molecules did not show any obviously different distribution.

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Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Henri Dunant Road,
Bangkok 10330, Thailand.


Corresponding author, E-mail: pisal@siit.tu.ac.th

Received 26 Jul 2001, Accepted 6 Feb 2002