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Research Article
ScienceAsia 25 (1999) : 107-112 |doi: 10.2306/scienceasia1513-1874.1999.25.107
Preparation of a Novel Resin Derived
from Ion-Exchange Resin and its Evaluation
in Peptide- and Benzodiazepine Synthesis
Eric Lattmann*, David C Billington, Pornthip Arayaratb, Harjit Singh and Michael Offel
ABSTRACT: The preparation of an extremely cheap and novel resin synthesised from a commercially
available ion exchange resin is described. The free carboxylic acid group of the resin was converted into
a methylester. Subsequent reduction of this ester to the corresponding alcohol has been carried out in
one step, by using a solution of DIBAH as a reducing agent. The application of this resin for solid phase
combinatorial synthesis has been evaluated by synthesizing 2 representative peptides and 2 selected
1,4-benzodiazepines.
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a Pharmaceutical Sciences Research Institute, Aston University, Birmingham B4 7ET England. Fax: +44-(0)121 359 3611, e-mail: e.lattmann@aston.ac.uk
b Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
* Corresponding author.
Received 7 May 1999
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