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Short Report

ScienceAsia 17 (1991): 137-140 |doi: 10.2306/scienceasia1513-1874.1991.17.137

 

RAPID SEPARATION OF HUMAN NORMAL AND ABNORMAL GLOBIN PEPTIDE CHAINS BY FPLC TECHNIQUE

 

SUCHET CHAICHAROEN

ABSTRACT: The separation of human abnormal and normal globin peptide chains by Fast Protein Liquid Chromatography (FPLC) system has been developed. The chromatographic conditions can separate , , E, and from each other in less than 30 minutes. This rapid separation reduces long time-consuming process of prenatal diagnosis of thalassemic disease.

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Division of Hematology Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok 10700, Thailand.

Received 20 March 1991