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Short Report

ScienceAsia 15 (1989): 261-266 |doi: 10.2306/scienceasia1513-1874.1989.15.261

 

THE PRESENCE OF DIMETHYLNITROSAMINE IN FERMENTED FISHES AND ITS MUTAGENICITY

 

PRASONG KOONANUWATCHAIDET AND CHAILAI SRISUWAN

ABSTRACT: Partially purified dimethylnitrosamine (DMN) from sixty batches of uncooked fermented fish extracts from the northeast of Thailand was quantitatively investigated. Only 8.33 percent tested negative for this carcinogen, and levels of positive samples were in the range of 42 to 1,228 ppb. ITS mutagenic response was also assayed by S. typhimurium with a microsomal system. A fairly good correlation was found between the presence of DMN and its mutagenesis action in these extracts.

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Department of Biochemistry, Faculty of Medicine, Khon-Kaen University, Khon-Kaen 40002, Thailand.

Received 27 June 1989