 BackShort Report ScienceAsia 15 (1989): 049-054 |doi: 10.2306/scienceasia1513-1874.1989.15.049
ANTHELMINTIC EFFECTS OF ALBENDAZOLE, MEBENDAZOLE AND DIETHYLCARBAMAZINE ON TRICHINELLA SPIRALIS IN MICE
ANGOON KEITTIVUTI AND BOONYIAM KEITTIVUTIABSTRACT: The efficacy of albendazole, mebendazole and diethylcarbamazine on Trichinella spiralis infection in mice was determined. Four groups of animals were treated with drugs, each at a dose of 50 mg/kg body weight for 3 consecutive days on days 2-4, 10-12, 21-23, and 28-30 post inoculation. Mter 35-42 days, infected mice were examined for trichinella larvae. Mebendazole and albendazole were effective in eliminating, respectively, 99.77% and 99.95% of worms in the intestines of infected mice, while diethylcarbamazine could noteliminare worms. During the invasive phase, the efficacy of mebendazole and diethylcarbamazine were nearly the same (76.21% and 72.85% respectively) while albendazole showed a 36.22% decrease in larva. Mebendazole not only prevented 97.91% of the larvae in muscle from entering the musculature phase, but it also reduced the larvae by 96.70% during the encapsulated phase. Moreover, albendazole and diethylcarbamazine decreased the amount of larvae in muscle from entering the musculature phase by 50.59% and 16.05% respectively. For the musculature phase wc observed that albendazole reduced 63.76% of the encapsulated larvae in muscle but diethylcarbamazine could not eliminate the encapsulated larvae. Mebendazole proved to be more effective than albendazole and diethylcarbamazine. Side effects such as conjunctivitis and ruffled hair were transiendyobserved after treatment with mebendazole and albendazole during the musculature phase. Department of Parasitology, Faculty of Public Health, Mahidol University, Bangkok 10400, Thailand. Received 30 November 1988
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