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Research Article


ScienceAsia 14 (1988): 197-208 |doi: 10.2306/scienceasia1513-1874.1988.14.197

 

DEVELOPMENT OF ZINGIBER CASSUMUNAR FOR ASTHMATIC TREATMENT : PHARMACOKINETICS IN ANIMALS

 

R. KOYSOOKO, P. VARAVUDHI,a T. PINTHONG AND J. WATTANAPERMPOOL

ABSTRACT: Pharmacokinetic studies of Plai preparation prepared from an ethanolic extract of Zingiber cassumunar rhizome were performed in rats and monkeys. The apparent first order transfer rate constant, using in situ intestinal loop technique, was found to be 0.0731 min-1. In vivo study by oral administration of drug to rats and determination of the concentration of bronchodilating active component of this plant in plasma also showed rapid absorption with a rate constant of 0.0385 min-1. Maximum plasma level of 0.75 g/ml was observed at 1.04 hours after drug administration. Elimination half-life in monkeys (2.31 hours) was found to be not statistically different from rats (2.00 hours). Prolonged half-life after multiple dosing was observed in monkeys. An accumulation ratio of 3.13 was found after long term drug administration. The pharmacokinetic parameters obtained from this study provides valuable information for future use in clinical evaluation of Zingiber cassumunar for the treatment of asthmatic patients. The study is also of benefit as a model for pharmacokinetic studies of other medicinal plants.

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Division of Medical Research, Department of Medical Sciences, Ministry of Public Health.
a Primate Research Unit, Chulalongkorn University and Chulabhorn Research Institute.

Received 18 April 1988