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Short Report

ScienceAsia 13 (1987): 107-112 |doi: 10.2306/scienceasia1513-1874.1987.13.107

 

TRADITONAL MEDICINAL PLANTS OF THAILAND VII. ALKALOIDS OF EVODIA LEPTA AND EVODLA GRACILIS*

 

Y.A.G.P. GUNAWARDANA,1 GEOFFREY A. CORDELL,1 NIJSIRI RUANGRUNGS,2 SINTHOP CHOMYA2 AND PAYOM TANTIVATANA2

ABSTRACT: An examination of the alkaloid content of Evodia lepta and Evodia gracilis has revealed that they are chemically distinct. Thus kokusaginine (1) and skimmianine (2) were obtained from E. gracilis, while (-)-edulinine (3), (-)-ribalinine (4) and (+)-isoplatydesmine (5) were obtained from E. lepta. Both 4 and 5 underwent rea"angement under basic conditions to the corresponding angular isomers. (-)-Ribalinine (4) also rearranged and underwent ring contraction in the presence of NaB to afford (+)- -isoplatydesmine (7).

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1 Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, U.S.A.
2 Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10500, Thailand

Received 26 December 1986