ScienceAsia 12 (1986): 141-157 |doi: 10.2306/scienceasia1513-1874.1986.12.141

STUDIES ON THE EFFECTS OF GOSSYPOL IN MALE CYNOMOLGUS MONKEY. IV. HISTOPATHOLOGICAL FINDINGS

SUKUMAL CHONGTHAMMAKUN,^a KANOK PAVASUTHIPAISIT,^a PANTHEP RATTANAKORN,^b M.R. PUTTIPONGSE VARAVUDHI^c

ABSTRACT: To investigate the toxicity of gossypol in subhuman primate, gossypol acetic acid (10 mg/kg/day) was administered intramuscularly to male cynomolgus monkeys, Macaca fascicularis for 2 weeks. After autopsy and complete postmortem examinations of 28 organs. histopathological changes were found in several vital organs. The liver and lungs showed congestion and hydropic degeneration. The spleen was congested and showed evidence of extramedullary hematopoiesis. The stomach and intestines demonstrated mucosal degeneration with accumulated brown pigments accompanied by macrophage infiltration in intestinal lamina propria. The kidneys showed mild hydropic degeneration of the renal tubules. Degenerative changes were also noted in the seminiferous tubules. Lysis of skeletal muscle fibers and erythrocytes was marked. It is concluded that gossypol. which is an effective antifertility agent in several mammalian species. exhibits a wide spectrum of toxicity in cynomolgus monkeys.

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a Department of Anatomy, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
b Department of Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
c Department of Biology, Faculty of Science, Chulalongkorn University, Bangkok 10500, Thailand.

Received 13 May 1986