ScienceAsia 9 (1983): 233-243 |doi: 10.2306/scienceasia1513-1874.1983.09.233

DIFFERENT PATTERNS OF INTRAMITOCHONDRIAL CALCIFICATION

SOMPHONG SAHAPHONG,^a SUDA RIENGROJPITAK^a and BENJAMIN F.TRUMP^b

ABSTRACT: Using isolated rat kidney mitochondria prepared in 0.25 M sucrose medium with EDT A for maximum loading by calcium, the patterns of mitochondrial calcium uptake were studied. If the mitochondria were allowed to accumulate large amount of calcium long needle like crystals were seen, and when the lesser amount was taken up the annular pattern was observed. Therefore, it is assumed that differences in the morphology of the calcification within mitochondria from needle like crystals to annular or ringlet pattern are due to the amount of calcium taken up by the mitochondria.

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a. Department of Pathabiology, Faculty of Science, Mahidol University, Bangkok, Thailand.
b. Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, U.S.A.

Received 15 August 1983