ScienceAsia 8 (1982): 215-223 |doi: 10.2306/scienceasia1513-1874.1982.08.215

ACYLATION OF 2-ARYL-2-DIMETHYLAMINOACETONITRILES. SIMPLE SYNTHESES OF UNSYMMETRICAL -DICARBONYL COMPOUNDS AND -KETOESTERS

VICHAI REUTRAKUL^a, SURACHAI NIMGIRAWATH,^b VICHUKORN PRAPANSIRI^a and YUPAYAO SRIKIRIN^a

ABSTRACT: Reactions of 2-lithio anions derived from 2-aryl-2-dimethylaminoacetonitriles with acyl halides or ethyl chloroformate followed by hydrolysis with copper (II) sulfate in 95% ethanol provide convenient syntheses of various unsymmetrical -diketones and -ketoesters, respectively.

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a Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand.
b Department of Chemistry, Faculty of Science, Silpakorn University, Nakorn Pathom, Thailand.

Received 4 June 1982