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Short Report


ScienceAsia 1 (1975): 233-239 |doi: 10.2306/scienceasia1513-1874.1975.01.233

 

DISPOSITION TOLERANCE TO METHADONE

 

AMNUAY THITHAPANDHA and PETER GOLD MAN

Summary: Evidence is presented in this paper to indicate that tolerance to methadone, a widely used synthetic narcotic, is dispositional in nature-i.e., metabolic inactivation of this narcotic does increase, with a resulting tolerance to its toxic properties. This is in contrast to tolerance to most narcotics such as morphine, because morphine tolerance seems to be adaptive or cellular tolerance.

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Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, and Clinical Pharmacology Unit, Harvard Medical School, Beth Israel Hospital, Boston, Mass. 02215.

Received 20 October 1975