ScienceAsia 1 (1975): 233-239 |doi: 10.2306/scienceasia1513-1874.1975.01.233
DISPOSITION TOLERANCE TO METHADONE
AMNUAY THITHAPANDHA and PETER GOLD MAN
Summary: Evidence is presented in this paper to indicate that tolerance to methadone, a widely used synthetic narcotic, is dispositional in nature-i.e., metabolic inactivation of this narcotic does increase, with a resulting tolerance to its toxic properties. This is in contrast to
tolerance to most narcotics such as morphine, because morphine tolerance seems to be adaptive
or cellular tolerance.
Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, and Clinical Pharmacology Unit, Harvard Medical School, Beth Israel Hospital, Boston, Mass. 02215.
Received 20 October 1975