Radiation protection of polysaccharides from Stropharia rugosoannulata

Xiaofei Liang^a,?, Chen Ruan^a,?, Chenxi Wu^a, Huiguo Xie^a, Lujie Yang^a, Wei Wu^b, Yingying Zhang^b,, Xinhong Wang^c,

ABSTRACT: Inthisstudy, polysaccharides from Stropharia rugosoannulata (Stropharia rugosoannulata polysaccharides, SRP) were extracted using aqueous extraction and alcohol precipitation, followed by purification through the Sevag deproteinization method. A radiation-damaged model was established in C57BL/6J mice. The immunomodulatory function and radiation-protective effects of SRP were evaluated using indicators including mouse body weight growth curves, immune organ indices, serum inflammatory factor levels, and histopathological changes in the spleen, thymus, colon, and liver. The results revealed that SRP not only significantly enhanced immune organ indices but also effectively suppressed inflammatory cytokine secretion, mitigating tissue damage in the spleen, thymus, liver, and colon.

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^a	School of Pharmacy, Shandong University of traditional Chinese Medicine, Jinan 250355 China
^b	School of Medicine, Shandong University of traditional Chinese Medicine, Jinan 250355 China
^c	Department of Periodontology, Central Laboratory, Jinan Key Laboratory of Oral Tissue Regeneration, Jinan Stomatological Hospital, Jinan 250000 China

* Corresponding author, E-mail: zyy8965@163.com, xinhongwang325@163.com

Received 24 Nov 2025, Accepted 13 Apr 2026

Radiation protection of polysaccharides from Stropharia rugosoannulata

Xiaofei Lianga,?, Chen Ruana,?, Chenxi Wua, Huiguo Xiea, Lujie Yanga, Wei Wub, Yingying Zhangb,*, Xinhong Wangc,*

Xiaofei Liang^a,?, Chen Ruan^a,?, Chenxi Wu^a, Huiguo Xie^a, Lujie Yang^a, Wei Wu^b, Yingying Zhang^b,, Xinhong Wang^c,