Research articles
ScienceAsia 51 (2023): 1-5 |doi:
10.2306/scienceasia1513-1874.2023.084
An alternate synthesis of mafenide acetate
Van Giang Nguyena, Chinh Khoa Nguyena, Nguyet Suong Huyen Daoa, Dinh Luyen Nguyena,
Anh Quang Luongb, Nguyen Trieu Trinhc, Van Hai Nguyena,*
ABSTRACT: Mafenideacetate(1)isanimportantantibacterialsubstancepopularlyusedtotreatburnwoundinfections,
especially second- and third-degree infected burns. In this paper, we report a novel, efficient and scalable method for
synthesizing mafenide acetate from low-cost materials. This robust synthesis requires minimal purification effort using
no column chromatography while affording the final product of high purity (99.18%, HPLC). In addition, we present
the spectral data (IR, NMR, and MS) for the key intermediate, N1,N4-bis(4-sulfamoylbenzyl)succinamide (3b), for the
f
irst time, providing a valuable reference for future research in the development of more potent mafenide derivatives.
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| a |
Faculty of Pharmaceutical Chemistry and Technology, Hanoi University of Pharmacy, Hanoi 110402 Vietnam |
| b |
Department of Pharmacy and Medical Equipment, National Burn Hospital, Hanoi 110402 Vietnam |
| c |
Centre for Organic Electronics, College of Engineering, Science and Environment, University of Newcastle,
New South Wales 2308 Australia |
* Corresponding author, E-mail: hainv@hup.edu.vn
Received 3 Oct 2023, Accepted 0 0000
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