Research articles
ScienceAsia 49 (2023):ID 391-402 |doi:
10.2306/scienceasia1513-1874.2023.028
Effects of different ethnicities and FOXC2 gene C-512T
polymorphisms on the intestinal flora: A study on healthy Dai
and Han populations in Yunnan
Lei Lianga, Hongjiang Zhoua, Elizabeth Raob, Xiaoyun Sua, Hua Liuc, Yandan Suc, Xuxiang Zhanga, Xin Niana,*
ABSTRACT: Present studies on ethnicity and intestinal flora show that different ethnic factors, such as diet, geography,
and genetics, can make remarkable differences in the structure of intestinal microbiota. To the best of our knowledge,
in this study, the differences in intestinal flora of healthy Dai and Han Chinese in the Yunnan region of China were
determined for the first time by high-throughput sequencing, and the correlation between polymorphisms of FOXC2
C-512T and the structure of intestinal flora was analyzed. The study found that there were significant differences in
? and ? diversity in intestinal flora between healthy Dai and Han people, and the two ethnic groups had dominant
microbiota, through analysis at gate and genus levels. Moreover, our study shows that the intestinal flora structure of
FOXC2 C-512T locus CT is different from that of the other two genotypes in terms of ? and ? diversity and that FOXC2
C-512T polymorphism can affect the composition of human intestinal flora. This study mainly fills the gap in the field
of ethnic-gut microbiome research of Dai people and reveals the effect of FOXC2 C-512T polymorphism on the structure
of human intestinal flora.
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| a |
The First Affiliated Hospital of Kunming Medical University, Department of Endocrinology, Kunming 650032 China |
| b |
Incinta Fertility Center, 21545 Hawthorne Boulevard Pavilion B, Torrance, CA 90503 USA |
| c |
The First Affiliated Hospital of Kunming Medical University, Clinical laboratory, Kunming 650032 China |
* Corresponding author, E-mail: nianxinkm@hotmail.com
Received 31 Jul 2022, Accepted 22 Dec 2022
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