 BackReview Article ScienceAsia 10 (1984): 207-220 |doi: 10.2306/scienceasia1513-1874.1984.10.207
N-NITROSO COMPOUNDS : ENVIRONMENTAL CARCINOGENS
PRASONG KOONANUWATCHAIDETABSTRACT: N-nitroso compounds are present in environmental media including in food. Although the concentrations found are in notably low range, the carcinogenic action of these compounds in experimental animals have been shown to occur in many different organs. Most of them are positively mutagenic in test systems. There is still inadequate quantitative and clinical data at present, but it is highly probable that N-nitroso compounds are carcinogenic in man. Human exposure to these carcinogens and their precursors should be kept as low as practically achievable. The information on their chemistry, formation, occurrence, toxic activity and possible evaluation of health risks to man is reviewed. Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand. Received 1 June 1984
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