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Volume 50 Number 2
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Research articles

ScienceAsia 50 (2024):ID 2024056 1-8 |doi: 10.2306/scienceasia1513-1874.2024.056

Formulation of chewable nutraceuticals prepared from banana fruit pulp and hemp seed oil

Chatnarong Putthonga, Prapapan Temkitthawonb, Preeyawass Phimnuana, Jarupa Viyocha,*, Kongaphisith Tongpoolsomjitc,*

ABSTRACT:     This study aimed to develop a chewable tablet nutraceutical by combining dried banana powder and coldpressed hemp seed oil as two major raw materials. Powdered bananas (Musa AA group) and hemp seed oil (Cannabis sativa L.) were obtained by grinding their respective lyophilized fresh fruit pulps. The chewable nutraceutical formula is composed of 70% w/w banana powder and 5% w/w hemp seed oil. The RP-HPLC analysis revealed that the banana powder contained 1,076.9?147.1 ?g of ?-carotene per gram. Oil extracted from hemp seeds contained 56.23% w/w linoleic acid (18:2n6) and 15.19% w/w alpha-linolenic acid (18:3n3) (omega 6 to omega 3; 4:1). In addition, the developed HPLC method showed that the oil contained cannabidiol (CBD) at a level of 21.85?0.91?10?4% w/w, with no traces of tetrahydrocannabinol (THC). The hardness of the nutraceutical was in the range of 45?5 N with the thickness in the range of 4?0.3 mm. It contained 1,080.0?55.2 ?g of ?-carotene per 1,200 mg tablet. The remaining content of ?-carotene after one month of storage at temperatures of 5?3 ?C and 32?3 ?C with relative humidity of 75?5% was 98.4% w/w and 90.5% w/w, respectively. Tablets must be protected against high heat and moisture to prevent ?-carotene oxidation. More study is required to establish the tablet effectiveness in the container under the label parameters such as dry air at room temperature for 1?2 years.

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a Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok 65000 Thailand
b Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000 Thailand
c Department of Industrial Chemistry, Faculty of Applied Science, King Mongkut?s University of Technology North Bangkok, Bangkok 10800 Thailand

* Corresponding author, E-mail: jarupav@nu.ac.th, kongaphisith.t@sci.kmutnb.ac.th

Received 21 Sep 2023, Accepted 24 Apr 2024