Research articles
ScienceAsia 51 (2023): 1-10 |doi:
10.2306/scienceasia1513-1874.2023.015
Treatment of 5-fluorouracil-induced chemotherapeutic
intestinal mucositis in mice by oral inulin via
glycerophospholipid and retinol metabolic pathways
Hao Dina,?, Yue Xib,?, Man Yanc, Chang Sunc, Jiajun Tanc, Zhengnan Yangd,*, Liang Wuc,*
ABSTRACT: 5-Fluorouracil (5-FU) is a commonly used chemotherapy drug, but there is no effective prevention and
treatment for the side effects of intestinal mucositis induced by 5-FU. Inulin is a type of fermentable dietary fiber,
which is non-digestible, and can improve metabolic function by modulating intestinal microbiota. The current study
is aimed at appraising the effect of inulin on 5-FU-induced intestinal mucositis in mice by non-targeted metabolomics.
The results indicated that oral inulin significantly inhibited 5-FU-induced body weight loss and intestinal shortening in
mice, inhibited NLRP3 inflammasome activation and IL-1? expression, and increased IL-10 and IgA expressions. Inulin
could significantly reduce intestinal mucosal injury induced by 5-FU in mice and significantly affected the production
of 27 different metabolites in mouse serum. These metabolites were closely related to glycerophospholipid metabolism
and retinol metabolic pathways. The study provided a potential new method for the prevention and treatment of
chemotherapeutic intestinal mucositis.
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| a |
Department of Respiratory Medicine, Zhenjiang First People?s Hospital, Zhenjiang 212002 China |
| b |
Medical Laboratory Department, Huai?an Second People?s Hospital, Huai?an 223022 China |
| c |
Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013 China |
| d |
Yizheng Hospital, Nanjing Drum Tower Hospital Group, Yizheng 210008 China |
* Corresponding author, E-mail: yang3638@sina.com, wlujs@ujs.edu.cn
Received 24 Jul 2023, Accepted 25 Dec 2024
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