ScienceAsia 51S (2023): 1-10 |doi:
10.2306/scienceasia1513-1874.2023.s013
From structure to function: Computational insights into
Musashi-RNA complexes in the context of viral pathogenesis
and beyond
Nitchakan Daraia, Leonhard Sidlb,c, Thanyada Rungrotmongkold, Peter Wolschannc,*,?,
Michael T. Wolfingerb,c,e,*
ABSTRACT: The Musashi (MSI) family of RNA-binding proteins, including MSI1 and MSI2, plays a crucial role in
the post-transcriptional regulation of gene expression. This review delves into the involvement of Musashi proteins
in the life cycle of RNA viruses, particularly their interaction with viral genomes. Emerging research highlights how
Musashi proteins, by binding to specific motifs such as UAG in viral RNA, modulate viral replication and influence
pathogenesis. Understanding these interactions is critical, as it reveals how viruses exploit host RNA-binding proteins
to enhance their replication and to open potential avenues for therapeutic intervention. We explore the structural
and computational insights into Musashi-RNA interactions using molecular dynamics simulations, docking studies,
and other computational approaches to provide a detailed understanding of Musashi?s role in viral pathogenesis.
Furthermore, we highlight potential therapeutic strategies targeting Musashi-RNA interactions to mitigate viral
diseases.
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| a |
Futuristic Science Research Center, School of Science, Walailak University, Nakhon Si Thammarat, Thailand |
| b |
Research Group Bioinformatics and Computational Biology, Faculty of Computer Science, University of Vienna,
Vienna, Austria |
| c |
Department of Theoretical Chemistry, University of Vienna, Vienna, Austria |
| d |
Department of Biochemistry, Chulalongkorn University, Bangkok, Thailand |
| e |
RNAForecast e.U., Vienna, Austria |
* Corresponding author, E-mail: karl.peter.wolschann@univie.ac.at, michael.wolfinger@univie.ac.at
Received 10 Nov 2024, Accepted 0 0000
|
