Research articles
ScienceAsia 50 (2024):ID 2024072 1-7 |doi:
10.2306/scienceasia1513-1874.2024.072
Pyrroloquinoline quinone mitigates glomerular filtration
barrier damages in diabetic mice
Dan Wua, Hamed Afsharib, Lei Chenc,*
ABSTRACT: Diabetic nephropathy (DN) is a common complication of diabetes and can lead to kidney failure if left
untreated. Pyrroloquinoline quinone (PQQ) is a natural compound that functions as both a redox cofactor and an
antioxidant. Accumulating evidence denotes that oxidative stress plays a central role in the development of renal injury
in diabetes, and the use of antioxidant agents is an effective approach to combat DN. In this study, we evaluated whether
PQQ has potential protective effects against glomerular damage due to DN by establishing type 1 diabetes in mice via
streptozotocin. We found that PQQ decreased renal malondialdehyde (MDA) levels and increased renal glutathione
peroxidase (GPX) activities. It also reduced renal tumor necrosis factor alpha (TNF-?) levels. PQQ significantly
decreased urinary excretions of albumin as well as specific podocyte damage markers, i.e. nephrin, synaptopodin, and
podocin. Additionally, it improved creatinine clearance (Ccr) and, at the same time, improved renal histoarchitecture.
Overall, these findings demonstrate the protective properties of PQQ against glomerular filtration barrier in diabetic
mice.
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| a |
Medical College, Yueyang Vocational and Technical College, Yueyang 414000 China |
| b |
Department of Mechanical and Bio-Mechanical Engineering, Urmia Branch, Islamic Azad University,
Urmia 5777893780 Iran |
| c |
Xinzhou District People?s Hospital, Integrated Traditional Chinese and Western Medicine, Hubei 430400 China |
* Corresponding author, E-mail: cl13098802617@163.com
Received 8 Oct 2023, Accepted 11 May 2024
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