Volume 49 Number 3

Cyclic intermittent hypoxia induces apoptosis through upregulation of LncRNA GAS5 expression in cardiomyocyte

Jiayuan Pu^a,b, Yan Zhao^b, Xue Bai^a, Tao Feng^a, Wenqiang Lu^a, Lihui Ding^a, Qin Yu^a

 
ABSTRACT:     Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is a common disorder that disrupts breathing during sleep, with known links to several heart-related conditions. Investigating the underlying mechanisms can guide the creation of new treatments. We focused on the role of specific genetic regulators, known as long non-coding RNAs (lncRNAs), which recent evidence suggests may play a part in heart disease resulting from OSAHS. Our study explored how a simulated OSAHS condition, Cyclic Intermittent Hypoxia (CIH), affects heart cells. We found that CIH increases levels of the lncRNA GAS5 and an enzyme called TRIM11, while reducing the levels of Bcl-2, a molecule that prevents cell death, thus leading to increased heart cell apoptosis. We also demonstrated that a microRNA, miR-205-5p, is a key player in this process, as it can modify the effect of GAS5 on TRIM11. Introducing miR-205-5p mimics lessened the impact of GAS5 on TRIM11. Our findings reveal a novel lncRNA GAS5/miR-205-5p/TRIM11 pathway by which OSAHS may cause heart damage. This research offers fresh insights into the molecular dynamics of heart injury induced by OSAHS and may inform future therapeutic strategies.

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* Corresponding author, E-mail: yuqin@lzu.edu.cn

Received 1 Aug 2023, Accepted 19 Apr 2024