Research articles
ScienceAsia 49 (2023): 275-281 |doi:
10.2306/scienceasia1513-1874.2023.020
Protective effects of resveratrol on nerves in rats with
Alzheimer's disease
Jun Lia,b, Chonghao Yuana,b, Xiaojun Hua,b,*
ABSTRACT: Alzheimer?s disease (AD), a degenerative disease of the central nervous system, is mainly treated by
cholinesterase inhibitors and memantine. We aimed to assess the protective effects of resveratrol (RES) on hippocampal
nerves in AD rats. Forty healthy Sprague-Dawley rats were assigned into model, blank, low-dose RES, and highdose RES groups (n = 10). After modeling, RES groups were daily injected with corresponding doses of RES. Their
cognitive functions were tested on days 1, 5, 10, and 14. The cellular morphology was compared through hematoxylineosin staining. The levels of norepinephrine (NE), dopamine (DA), choline acetyltransferase (ChAT), malondialdehyde
(MDA), nitric oxide (NO), reactive oxygen species (ROS), activities of superoxide dismutase (SOD), inducible nitric
oxide synthase (iNOS), catalase (CAT), and glutathione peroxidase (GSH-Px) as well as total antioxidant capacity (TAOC) were detected. The expressions of Kelch-like ECH-associated protein 1 (Keap1) and nuclear factor E2-related
factor 2 (Nrf2) were measured using Western blotting. Compared with model group, the escape latency, the balance
beam score, the Longa score, and the levels of ROS, MDA, NO, and iNOS activity were significantly decreased in the
RES groups (p < 0.05); while the platform-crossing times, the levels of NE, DA and ChAT, the activities of CAT, GSHPx and SOD, T-AOC and protein expressions of Nrf2 and Keap1 were significantly increased (p < 0.05). Hippocampal
pathological changes were significantly relieved in the RES groups compared with those in the model group. RES exerts
protective effects on hippocampal neurons, regulates the neurotransmitter level, and reduces oxidative stress response,
probably by activating the Nrf2/ARE pathway.
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a |
Department of Traditional Chinese Medicine and Acupuncture, Wuhan Puren Hospital, Wuhan University of Science
and Technology, Wuhan 430081 China |
b |
Department of Rehabilitation Medicine, People?s Hospital of Liwan District, Guangzhou 510370 China |
* Corresponding author, E-mail: anlao599130@163.com
Received 20 Mar 2022, Accepted 8 Aug 2022
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