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The ameliorative effect of black soybean and purple sweet potato to improve sperm quality through suppressing reactive oxygen species (ROS) in type 2 diabetes mellitus rat (Rattus novergicus)

Abdul Gofur^a,*, Agung Witjoro^a, Erni Widya Ningtiyas^a, Evi Setyowati^a, Siti Aminatul Mukharromah^a, Suhartini^a, Mochammad Fitri Atho\\\'illah^b, Sri Rahayu Lestari^a

 
ABSTRACT:     Overproduction of reactive oxygen species (ROS) will promote oxidative damage and can induce reproductive disorder. A therapeutic strategy to reduce effects of reproductive disorder is by maintaining the balance between ROS and antioxidants. Black soybean (BSB) contain phenolic compounds and has a greater antioxidant capacity than yellow soybean. Purple sweet potato (PSP) also has antioxidant capacity, due to the presence of anthocyanin, but is low in protein. The combination of BSB and PSP is expected to limit symptoms of reproductive disorder through decreasing ROS levels, enhancing testosterone production, and improve sperm quality. The results of this study indicate that the combination of PSP and BSB could restore blood glucose levels, improve seminiferous tubules diameter, decrease ROS production, and improve testosterone and sperm quality. A ratio of BSB to PSP of 2:2 and 3:1 were effective to improve symptoms of reproductive disorder in the type 2 diabetes mellitus (T2DM) rat model.

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* Corresponding author, E-mail: abdul.gofur.fmipa@um.ac.id

Received 10 May 2018, Accepted 7 Nov 2018