Styryl-cyanine dyes: State of the art and applications in bioimaging

Kotchakorn Supabowornsathit^a,b, Kriangsak Faikhruea^a,b, Tirayut Vilaivan^a,*,?

ABSTRACT: Styryl-cyanine dyes, a class of conjugated organic molecules, have emerged as essential tools in bioimaging due to their exceptional optical properties. This review highlights recent advancements in the development of these dyes for bioimaging nucleic acids, cellular organelles, and proteins. Key molecular design strategies for developing target-specific probes and an overview of synthesis approaches, mechanisms of action, and biomolecular interactions are discussed. These insights underscore the versatility and critical role of styryl-cyanine dyes in advancing bioimaging technologies, offering enhanced capabilities for visualizing and understanding complex biological processes in living cells at the molecular levels.

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^a	Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330 Thailand
^b	Synna Science Co., Ltd., Faculty of Science, Chulalongkorn University, Bangkok 10330 Thailand

* Corresponding author, E-mail: vtirayut@chula.ac.th

Received 15 Jan 2025, Accepted 0 0000

Styryl-cyanine dyes: State of the art and applications in bioimaging

Kotchakorn Supabowornsathita,b, Kriangsak Faikhrueaa,b, Tirayut Vilaivana,*,?

Kotchakorn Supabowornsathit^a,b, Kriangsak Faikhruea^a,b, Tirayut Vilaivan^a,*,?