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Research articles

ScienceAsia 35 (2009): 24-30 |doi: 10.2306/scienceasia1513-1874.2009.35.024

Cleansing lotion containing tamarind fruit pulp extract. III. Study of lightening efficacy and skin irritation on Asian skin type

Ratree Maenthaisonga, Nathorn Chaiyakunaprukb, Prateep Warnnissornc, Jarupa Viyochd,e,*

ABSTRACT:     Cleansing lotion containing 8% w/w tamarind pulp extract was prepared and tested for its clinical effects on skin properties. The study was performed using 38 healthy Thai female volunteers, and consisted of a home-use, double-blind, randomized side of face and placebo controlled trial. The test product (emulsion with the extract) and the placebo product (emulsion without the extract) were applied and gently massaged on each side of facial skin for 2 minutes twice daily for 8 weeks and the difference in skin colour between test and placebo side of face was measured. In addition, redness, moisture content, pH and transepidermal water loss (TEWL) of skin, adverse events, subject's satisfaction, and compliance of volunteers were assessed. We found that the melanin value on the side where the test product was applied was significantly less than that of the other side at week 4 (p<0.015). The mean differences between the test and the placebo side of all skin parameters including melanin value, pH and moisture content elasticity were not significant (p>0.05) at the end of study (week 8). Erythema and TEWL of the skin were not different between the side on which the test was applied and the placebo side indicating that the product was safe. In addition, most volunteers were satisfied with the cleansing effect of the product containing the extract.

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a Department of Clinical Pharmacy and Research, Faculty of Pharmacy, Mahasarakham University, Mahasarakham, Thailand
b Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand
d Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand

* Corresponding author, E-mail: jarupav@nu.ac.th

Received 9 Jun 2008, Accepted 16 Feb 2009