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Research articles

ScienceAsia 50 (2024):ID 2024050 1-7 |doi: 10.2306/scienceasia1513-1874.2024.050

Antibacterial and antioxidant aromatic butenolide derivatives from the endophytic fungus Aspergillus flavipes XC5-7

Lulu Liua, Pan Wub, Rongya Zhanga, Yaping Maa, Zhishun Chaia, Yongwei Liangb, Honghui Dongb, Guofeng Yuc,*, Ting Zhoua, Lei Xinga,*, Tianxiao Lib,*

ABSTRACT:     Five bioactive aromatic butenolide derivatives were isolated from ethyl acetate (EtOAc) extracts of the endophytic fungus Aspergillus flavipes XC5-7, which was isolated from tobacco in China. Their structures were identified by 1H nuclear magnetic resonance (NMR), 13C NMR, and mass spectrometry (MS) spectroscopic analyses as aspernolide C (1), aspernolide H (2), butyrolactone II (3), aspulvinone P (4), and aspulvinone Q (5). Compound 1 exhibited significant antimicrobial activity against ten strains of bacteria with minimal inhibitory concentrations (MICs) in the range of 6.6 to 27.9 ?g/ml, especially against Enterococcus faecalis (MIC = 7.7 ?g/ml) and Escherichia coli (MIC = 6.6 ?g/ml). Aspulvinone P (4) and aspulvinone Q (5) were found to exhibit prominent antioxidant effects for the first time, with potencies [EC50 (half effective) = 13.3 and 16.0 ?M] that were two-fold greater than those of the positive control Trolox (EC50 = 32.7 ?M) in 2,2-di(4-tert-octylphenyl)-1-picrylhydrazyl free radical (DPPH) assays. In addition, the antibacterial and antioxidant structure-function relationships of these compounds were also studied and discussed.

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a China Tobacco Sichuan Industrial Co., Ltd., Chengdu 610051 China
b College of Food and Biological Engineering, Zhengzhou University of Light Industry, Zhengzhou 450001 China
c China Tobacco Shandong Industrial Co., Ltd., Qingdao 266100 China

* Corresponding author, E-mail: jingyu825158@163.com, 304083106@qq.com, litianxiao1012@163.com

Received 30 Jul 2023, Accepted 21 Apr 2024