| Home  | About ScienceAsia  | Publication charge  | Advertise with us  | Subscription for printed version  | Contact us  
Editorial Board
Journal Policy
Instructions for Authors
Online submission
Author Login
Reviewer Login
Volume 50 Number 1
Volume 49 Number 6
Volume 49 Number 5
Volume 49S Number 1
Volume 49 Number 4
Volume 49 Number 3
Earlier issues
Volume  Number 

previous article next article

Research articles

ScienceAsia 49 (2023):ID 873-879 |doi: 10.2306/scienceasia1513-1874.2023.096

Antioxidant, cytotoxic activities, and phytochemical compositions of the Thai traditional medicine Trikanrapit remedy

Anusara Sihanata, Arunporn Itharatb,c, Patsorn Worawattananutaid, Kriyapa Lairungruange, Nattiya Chaichamnonga, Nobpawan Watcharaputa, Pawarisa Noppakaoa, Rodsarin Yampraserta,*

ABSTRACT:     Trikanrapit (red basil roots, galangal rhizome, and fingerroot) is a traditional Thai herbal remedy used to cure body impairment, nourish blood and sexual desire, and as a carminative drug. This study aimed to investigate the antioxidant activity via 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging (DPPH), 2,2? - azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation decolorization (ABTS), ferric ion reducing antioxidant power (FRAP) assay and cytotoxic activity via a sulforhodamine B assay. The chemical constituents of the extracts were analyzed using gas chromatography-mass spectrometry (GC-MS). The results indicate that the ethanolic extract of Trikanrapit remedy showed good antioxidant activity, and the root extract of Ocimum tenuiflorum, one of the three herb constituents, exhibited strong antioxidant activity on the DPPH and ABTS?+ assays. The Trikanrapit remedy extract showed moderate cytotoxicity against LS174T colorectal adenocarcinoma cells and human lung adenocarcinoma A549 cells, with 50% maximal inhibitory concentration (IC50) values of 52.04 and 46.85 ?g/ml, respectively. While the root extract of O. tenuiflorum showed high cytotoxicity activities on both the LS174T and A549 cell lines, with IC50 values of 31.51 and 29.60 ?g/ml, respectively. Moreover, Trikanrapit extract contains approximately 47 different compounds. In addition, the data discussed in this study revealed cytotoxic and antioxidant properties, which correspond to the traditional Thai theory of using herbal recipes to treat various diseases.

Download PDF

102 Downloads 419 Views

a Division of Applied Thai Traditional Medicine, Faculty of Public Health, Naresuan University, Phitsanulok 65000 Thailand
b Department of Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120 Thailand
c Center of Excellence in Applied Thai Traditional Medicine, Faculty of Medicine, Thammasat University, Pathum Thani 12120 Thailand
d Faculty of Allied Health Sciences, Burapha University, Chonburi 20131 Thailand
e Abhaibhubejhr College of Thai Traditional Medicine Prachinburi, Faculty of Public Health and Allied Health Sciences, Praboromarajchanok Institute, Ministry of Public Health, Prachin Buri 25230 Thailand

* Corresponding author, E-mail: rodsariny@nu.ac.th

Received 23 May 2023, Accepted 23 Sep 2023