Research articles
ScienceAsia 50 (2024):ID 2024080 1-7 |doi:
10.2306/scienceasia1513-1874.2024.080
Pyrroloquinoline quinone protects against
doxorubicin-induced cardiotoxicity in mice by modulating
Nrf2 and NF-kB activities
Hechao Wanga, Junchao Lib,*
ABSTRACT: Pyrroloquinoline quinone (PQQ) is a potent antioxidant cofactor that is widely distributed in the animal
and plant tissues and is considered to be an indispensable nutrient in the mammals. In the present investigation, we
examined PQQ effects on doxorubicin (DOX)-induced cardiotoxicity in mice. The animals received a single 15-mg/kg
intraperitoneal dose of DOX injection at day 1. A daily oral dose of 10 mg/kg PQQ were administered to the mice in the
study group. Nuclear factor kappa beta (NF-kB) and nuclear factor erythroid 2related factor 2 (Nrf2) activities were
measured in the nuclear fractions of cardiac tissue homogenates. Cardiac histopathology and function, as well as serum
markers of cardiac injury and tissue markers of inflammation and oxidative stress were examined. PQQ improved Nrf2
activity and at the same time suppressed NF-kB activity. PQQ reduced cardiac levels of tumor necrosis factor ? (TNF?) and malondialdehyde (MDA), and elevated tissue activities of superoxide dismutase (SOD). PQQ decreased serum
levels of creatinine kinase MB (CK-MB) and cardiac troponin I (cTnI), and improved histopathological indices of cardiac
injury as well as cardiac function. Altogether, these findings emphasize that PQQ is protective against DOX-induced
cardiotoxicity in mice by modulating NF-kB and Nrf2 pathways.
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| a |
Yangfang Outpatient Department, The Northern Medical District, Chinese PLA General Hospital,
Beijing 100094 China |
| b |
Internal Medicine Department, Qinghe Branch Hospital of Beijing Bureau of Prisons, Beijing 100000 China |
* Corresponding author, E-mail: lijunchao0910@sina.com
Received 13 Apr 2023, Accepted 10 Jul 2024
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