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Volume 49 Number 3 Volume 49 Number 4

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Research articles

ScienceAsia 49 (2023): 515-522 |doi: 10.2306/scienceasia1513-1874.2023.039

Green extraction technique to separate bioactive compounds from coffee husk waste using natural deep eutectic solvent based on choline chloride-proline

Askal Maimulyantia,*, Anton Restu Prihadib, Inda Mapiliandaria

ABSTRACT:     The focus of developing analytical methods in sample preparation is directed at green chemistry. This has led to the recent development of a green solvent that uses natural deep eutectic solvent (NADES) in the extraction process. Therefore, this study presents the application of choline chloride and proline-based NADES in analytical chemistry as a green solvent, resulting in an extraction yield of 2.8%. The extracted compounds were analyzed using liquid chromatography-mass spectrometry (LC-MS), which identified 17 compounds with m/z values. The main compounds with retention time were caffeic acid (6.675 min), chlorogenic acid (6.056 min), 4,5-dicaffeoylquinic acid (9.628 min), (+/?)12(13)-dihydoxyoctadec-9-enoic acid (DiHOME) (17.231 min), D-(-)-quinic acid (6.051 min), and neochlorogenic acid (4.713 min). The use of NADES as a green solvent offers an attractive alternative method for extracting active compounds from the coffee husk, with potential applications in pharmaceuticals.

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a Department of Analytical Chemistry, AKA Bogor Polytechnic, Bogor 16154 Indonesia
b Department of Quality Assurance of Food Industry, AKA Bogor Polytechnic, Bogor 16154 Indonesia

* Corresponding author, E-mail: askal_m@yahoo.com

Received 19 Dec 2022, Accepted 5 Apr 2023