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Variations in total phenolics in Sargassum plagiophyllum and their cytotoxic activities

Raphatphorn Navakanitworakul^a, Dailamee Wanso^a, Sinjai Phetcharat^b, Parinuch Chumkaew^c, Jaruwan Mayakun^b,*

 
ABSTRACT:     The brown alga Sargassum plagiophyllum is one of the most abundant species in the Andaman Sea. It is rich in phenolic compounds that show variations possibly influenced by biotic and abiotic factors. In the present study, variations of total phenolic compounds within-thallus and in different life stages were investigated, and the cytotoxicity of the phenolic compounds were evaluated against cancer cell proliferation. The results showed that total phenolic compounds in S. plagiophyllum significantly differed within-thallus with the highest concentration being found in the reproductive cells. There was significant difference in concentrations among life stages, with the lowest concentration found in juvenile plants. Total phenolic compounds revealed anticancer activity against colon (HCT116 and PMF-k014) and cervical cancer cells (HeLa and SiHa). The cytotoxic activity of the extracted phenolics produced half-maximal inhibitory concentrations (IC50 values) of >80 ?g/ml against the cell lines HCT116 and PMF-k014, and of 44?11.4 and 41.9?6.1 ?g/ml against HeLa and SiHa, respectively. Overall, this work found that total phenolic compounds from S. plagiophyllum have potential health benefits. In addition, the results of the study imply that to collect and use total phenolic compounds of S. plagiophyllum efficiently and sustainably, parts of the thallus and life stages should be carefully considered.

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* Corresponding author, E-mail: jaruwan.may@psu.ac.th

Received 27 Nov 2022, Accepted 2 Aug 2023