ScienceAsia 47 (2021): 665-672 |doi:
10.2306/scienceasia1513-1874.2021.109
Therapeutic opportunities for cancers presented by
natural and synthetic compounds targeting the Hippo
signaling pathway
Thanapon Charoenwongpaiboona, Chuti Laowtammathronb, Chanchao Lorthongpanichb,*
ABSTRACT: A new trend in anti-cancer treatments through the disruption of the YAP-TEAD protein-protein interaction
complex is recognized. YAP has been tipped as a key modulator of the Hippo signaling pathway. Binding of YAP to
its transcription factor TEAD can lead to disease progression as it drives cell-proliferation and triggers anti-apoptosis
signaling. Recent studies have uncovered promising activities of various small molecules for regulating components
of the Hippo signaling pathway. By using a structural elucidation and computational approach, some small molecules
are able to bind on the YAP-TEAD interaction interface and inhibit the Hippo pathway. This review highlights our
current understanding of how natural and synthetic molecules regulate Hippo signaling activity and suggests how
phytochemical compounds available today can target the YAP-TEAD protein interaction complex to eradicate cancer
cells.
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| a |
Department of Chemistry, Faculty of Science, Silpakorn University, Nakhon Pathom 73000 Thailand |
| b |
Siriraj Center of Excellence for Stem Cell Research, Department of Medicine, Faculty of Medicine Siriraj
Hospital, Mahidol University, Bangkok 10700 Thailand |
* Corresponding author, E-mail: chanchao.lor@mahidol.ac.th
Received 30 Sep 2021, Accepted 0 0000
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