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Research articles

ScienceAsia 48 (2022):ID 552-557 |doi: 10.2306/scienceasia1513-1874.2022.083

Antioxidative potential of alpha-mangostin against hydrogen peroxide induced oxidative stress in human sperm

Wanlapa Kokmasa, Onrawee Khongsombatb, Hathairat Kruevaisayawanc, Waree Tiyaboonchaid, Patcharada Amatyakule,*

ABSTRACT:     Oxidative stress has detrimental effects on sperm viability and fertility, and antioxidant supplementation can improve sperm quality and function. Alpha-mangostin (?-MG) has high potential antioxidants, but its effects on human sperm quality have not been thoroughly explored. This study aimed to investigate the effects of ?-MG on sperm motility, acrosome reaction after ionophore challenge (ARIC), enzymatic antioxidative activities, and malondialdehyde (MDA) levels in human sperm. Semen samples from 30 men were subjected to 150 ?M of H2O2 (to induce oxidative stress) and various combinations of ?-MG (25 ?M and 50 ?M). The results indicated that supplementing sperm with ?MG at 25 ?M and 50 ?M significantly increased the percentage of progressive sperm motility. Both ?-MG concentrations resulted in significant reduction in the ARIC index. MDA levels in samples supplemented with ?-MG were lower than in samples without ?-MG. The concentration of ?-MG at 50 ?M substantially improved the catalase activity, and at 25 ?M, substantially enhanced the glutathione peroxidase (GPx) activity. In summary, supplementation of ?-MG optimized the motility and acrosome reaction index of human sperm exposed to oxidative stress.

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a Center for Animal Research, Naresuan University, Phitsanulok 65000 Thailand
b Department of Physiology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000 Thailand
c Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000 Thailand
d Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000 Thailand
e Department of Obstetrics and Gynecology, Faculty of Medicine, Naresuan University, Phitsanulok 65000 Thailand

* Corresponding author, E-mail:

Received 20 Sep 2021, Accepted 31 Mar 2022