Research articles
ScienceAsia 48 (2022):ID 429-433 |doi:
10.2306/scienceasia1513-1874.2022.059
Cytotoxic compounds from Goniothalamus repevensis Pierre
ex Finet & Gagnep
Waraporn Chanakula,*, Vichai Reutrakulb, Chutima Kuhakarnb, Samreang Bunteangb, Pawinee Piyachaturawatc, Kanoknetr Suksenc, Sakchai Hongthongd, Sariyarach Thanasansurapongb, Narong Nuntasaene
ABSTRACT: Phytochemical investigation of the methanol extract of the leaves and twigs of Goniothalamus repevensis
led to the isolation of five known compounds including two styryl lactones; (?)-goniodiol-7-monoacetate (1) and
(?)-goniodiol diacetate (2) as well as three aristolactam alkaloids; piperolactam C (3), aristolactam A III (4), and
aristolactam B III (5). The structure determination was established by various spectroscopic methods and by comparison
with the literature data. Cytotoxic activity against a panel of mammalian cancerous cell lines of compounds 1?4
was investigated. Piperolactam C (3) was found to be active in all tested cell lines with IC50 values in the range of
3.30?64.6 ?M. (?)-Goniodiol-7-monoacetate (1) exhibited cytotoxic activity only against ASK cells with IC50 value of
10.28 ?M. Having been isolated as a major component, compound 1 can be considered chemotaxonomic significance
for G. repevensis.
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| a |
Faculty of Science, Energy and Environment, King Mongkut?s University of Technology North Bangkok,
Rayong Campus, Rayong 21120 Thailand |
| b |
Department of Chemistry and Center Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science,
Mahidol University, Bangkok 10400 Thailand |
| c |
Department of Physiology, Faculty of Science, Mahidol University, Bangkok 10400 Thailand |
| d |
Division of Chemistry, Faculty of Science and Technology, Rajabhat Rajanagarindra University,
Chachoengsao 24000 Thailand |
| e |
Department of National Parks, Wildlife and Plant Conservation, Ministry of Natural Resources and Environment,
The Forest Herbarium, Bangkok 10900 Thailand |
* Corresponding author, E-mail: waraporn.c@sciee.kmutnb.ac.th
Received 31 Aug 2021, Accepted 22 Jan 2022
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