Research articles
ScienceAsia 47 (2021):ID 733-740 |doi:
10.2306/scienceasia1513-1874.2021.108
Effects of pyriproxyfen exposure on damage to midgut
and related gene expressions in the Bombyx mori
silkworm
Huimin Guoa,†, Xiao Zhanga,†, Juan Suna, Xin Zhenga, Guodong Zhaoa,b, Gang Lia,b, Heying Qiana,b,*
ABSTRACT: Silkworm is an important economic insect and very sensitive to pesticides. The pollution of pyriproxyfen
leads to the detriment of the growth and cocooning of the silkworm, which seriously affects the development of
sericulture. Results showed that at 24 h and 48 h after pyriproxyfen exposure, the relative expressions of digestive
enzyme genes, oxidative phosphorylation genes, and antioxidant enzyme genes were reduced, suggesting the inhibition
of pyriproxyfen on digestion and absorption, energy metabolism, and antioxidation in the midgut of a silkworm.
However, the activities of detoxification enzymes and the expressions of detoxification-related genes were elevated in
the midgut of silkworm after 24 h and 48 h of pyriproxyfen exposure, indicating the enhanced resistance of silkworm to
pyriproxyfen. In general, this study revealed the silkworm's midgut response to pyriproxyfen and provided an important
reference to understand the metabolic mechanism of pyriproxyfen in this insect.
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| a |
School of Biotechnology, Jiangsu University of Science and Technology, Jiangsu 212018 China |
| b |
Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Jiangsu 212018 China |
* Corresponding author, E-mail: qhysri@just.edu.cn
Received 5 Jul 2021, Accepted 8 Oct 2021
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