Research articles
ScienceAsia 48 (2022):ID 406-413 |doi:
10.2306/scienceasia1513-1874.2022.066
Berberine ameliorates lipopolysaccharide-induced astrocyte
activation and migration via NDUFC2
Hua Xu*, Minhao Chen
ABSTRACT: Astrocytes are an abundant cell type in central nervous system (CNS) and play a critical role in CNS
homeostasis. Abnormal astrocytes have been consistently observed in diverse CNS diseases, which lead to enlarged
inflammatory reactions and glial scars. As a naturally extracted monomer with anti-inflammatory properties, berberine
shows a potential therapeutic effect on abnormal astrocytes. However, the mechanism of berberine in the regulation
of abnormal astrocytes is still unclear. Here, we have shown that berberine restored lipopolysaccharide (LPS)-induced
mitochondrial abnormalities by upregulating NDUFC2, a subunit of ubiquinone oxidoreductase, expression resulting in
astrocyte rehabilitation. Pretreatment of 10 ?g/ml berberine inhibited LPS-induced astrocyte activation and migration.
The knockdown of NDUFC2 repressed the inhibitory action of berberine on LPS-induced astrocyte activation and
migration; and, as a result, mitochondria injury was increased. These findings prove a new mechanism in astrocyte
reaction and provide a potential curative target of berberine for inflammatory diseases.
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Department of Orthopaedics, Affiliated Hospital of Nantong University, Nantong University, Jiangsu 226001 China |
* Corresponding author, E-mail: xuhua1981111@126.com
Received 3 Jul 2021, Accepted 9 Feb 2022
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