Research articles
ScienceAsia 47S (2021):ID 14-18 |doi:
10.2306/scienceasia1513-1874.2021.S002
Antioxidant and antimicrobial alkaloids isolated from
twigs of Uvaria grandiflora Roxb.
Naowarat Kongkuma, Sariyarach Thanasansurapongb, Nakin Surapanichc, Wiyarat Kumutanatc,
Chanchai Sukkumd, Chutima Kuhakarnb, Thaworn Jaipetchb, Vichai Reutrakulb,
Sakchai Hongthongb,c,*
ABSTRACT: Phytochemical investigation of the MeOH-EtOAc (1:1 v/v) soluble fraction partitioned from the MeOH
extract of twigs of Uvaria grandiflora Roxb. led to the isolation of six known compounds including aristolactam AII (1),
aristolactam BI (2), velutinam (3), griffithinam (4), isoursuline (5), and sinactine (6). Their structures were determined
on the basis of spectroscopic analysis and comparison with the literature data. Described in this work is the first report
of isoursuline (5), an azafluorene derivative, and sinactine (6), a tetrahydroepiberberine, being isolated from plants
in the Uvaria genus. Antioxidant and antimicrobial activities of some isolated compounds were evaluated. Among
screened compounds, velutinam (3) showed antioxidant activity in the DPPH radical scavenging assay.
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| a |
Division of Chemistry, Faculty of Science and Technology, Surindra Rajabhat University, Surin 32000
Thailand |
| b |
Department of Chemistry and Center Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of
Science, Mahidol University, Bangkok 10400 Thailand |
| c |
Division of Chemistry, Faculty of Science and Technology, Rajabhat Rajanagarindra University,
Chachoengsao 24000 Thailand |
| d |
Division of Occupational Health and Safety, Faculty of Science and Technology, Rajabhat Rajanagarindra
University, Chachoengsao 24000 Thailand |
* Corresponding author, E-mail: sakchai.hon@rru.ac.th
Received 11 Nov 2020, Accepted 19 Feb 2021
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