Marine Streptomyces chumphonensis KK1-2^T produces piericidin A1 as the major secondary metabolite

Wongsakorn Phongsopitanun^a,*, Pawina Kanchanasin^a, Ariya Khanboon^a, Pattama Pittayakhajonwut^b, Khanit Suwanborirux^c, Somboon Tanasupawat^a

ABSTRACT: Strain KK1-2^T is the type strain of marine Streptomyces chomphonensis. Since the discovery of this Streptomyces species, the secondary metabolite of the type strain has not been characterized. Based on genome sequence analysis, the biosynthetic gene cluster of piericidin A1 was detected in the genome of strain KK1-2^T. The isolation of secondary metabolites and spectroscopy data confirm the chemical structure of piericidin A1 produced by the type strain. This study is the first report of the genome analysis and the secondary metabolite produced by the type strain of S. chumphonensis.

Download PDF

202 Downloads 1019 Views

^a	Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330 Thailand
^b	National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Pathum Thani 12120 Thailand
^c	Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330 Thailand

* Corresponding author, E-mail: Wongsakorn.p@chula.ac.th

Received 24 Sep 2020, Accepted 11 Jan 2021

Marine Streptomyces chumphonensis KK1-2T produces piericidin A1 as the major secondary metabolite

Wongsakorn Phongsopitanuna,*, Pawina Kanchanasina, Ariya Khanboona, Pattama Pittayakhajonwutb, Khanit Suwanboriruxc, Somboon Tanasupawata

Marine Streptomyces chumphonensis KK1-2^T produces piericidin A1 as the major secondary metabolite

Wongsakorn Phongsopitanun^a,*, Pawina Kanchanasin^a, Ariya Khanboon^a, Pattama Pittayakhajonwut^b, Khanit Suwanborirux^c, Somboon Tanasupawat^a