Research articles
ScienceAsia 46 (2020):ID 686-690 |doi:
10.2306/scienceasia1513-1874.2020.086
An effective invasive therapeutic approach of
fluoro-substituted zinc phthalocyanine derivatives as
potential photosensitizer for prostate carcinoma
Tamer E. Youssefa,b,*, Suhailah S. Al-Jameela, Wafa M. Al-Magribia
ABSTRACT: Fluoro-substituted zinc(II)phthalocyanines (RS)4ZnPcs were prepared. All the structures of newly
synthesized compounds was evaluated by IR and 1H NMR spectral analysis. They were tested against human
adenocarcinoma prostate cancer cells. A type II membrane antigen highly expressed in prostate cancer, namely
prostate-specific membrane antigen, has been an attractive target for imaging and therapy. To investigate the structureactivity relationships of (RS)4ZnPcs 4a?c in human adenocarcinoma prostate cancer cell model, 3 fluoro-substituted
zinc(II)phthalocyanines with different terminal heteroaromatic rings have been designed and evaluated for their antiproliferative potency in vitro. The detailed LD50 values of the targeted compounds were reported. Our preliminary in
vitro studies confirm that (RS)4ZnPcs 4a?c could act as an attractive photosensitizer for the early diagnosis of prostate
cancer.
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| a |
Department of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University,
Dammam 31441 Saudi Arabia. |
| b |
Basic and Applied Scientific Research Center, Imam Abdulrahman Bin Faisal University,
Dammam 31441 Saudi Arabia. |
* Corresponding author, E-mail: temoustafa@iau.edu.sa
Received 14 Jan 2020, Accepted 30 Sep 2020
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