Research articles
ScienceAsia 47 (2021):ID 162-169 |doi:
10.2306/scienceasia1513-1874.2021.021
Alleviation of high-fat-diet induced obesity and
cholesterol accumulation in mice by extracts from male
zooid of Antheraea pernyi
Lin Zhu*, Guang Guo, Zuo-Qing Fan, Na Wang, De-Qing Zou, Xin-Qin Shi
ABSTRACT: In this paper, extracts from male zooid of Antheraea pernyi (EMZAP) were investigated for their antiobesity activity in C57BL/6 male mice. Mice were randomly divided into 4 groups and fed on basal control group diet
(Control Group), high-fat diet (Model Group), high-fat diet containing high dose of EMZAP (High Group), and high-fat
diet containing low dose of EMZAP (Low Group), respectively. The levels of serum lipid, antioxidant capacity, body
weight, and adipose weight were measured. The levels of expression of genes involved in cholesterol metabolism were
also determined by Real-Time PCR. The results showed that EMZAP could reduce body weight and epididymal adipose
weight of mice on fed high-fat diet, and also decrease serum lipid levels in mice with induced obesity. Treatment
with EMZAP also produced significant amelioration of lipid accumulation and improved the antioxidant capacity in the
liver. EMZAP reduced the expression of HMG-CoA reductase (HMG-CoA-R) and increased the expression of cholesterol
7-alpha hydroxylase (CYP7A1) and LDL receptor (LDLR replica watches). But it has no obvious effect on the expression of LXR?.
According to the above results, EMZAP had good anti-obesity attributes and improvement in conditions arising out of
cholesterol accumulation.
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* Corresponding author, E-mail: zhulin_0517@163.com
Received 28 Nov 2019, Accepted 26 Dec 2020
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